@article{1f7996e2105b403499dca36c4ec8dbba,
title = "One-step construction of carbazoles by way of the palladium-catalyzed double N-arylation reaction and its application to the total synthesis of murrastifoline-A",
abstract = "The one-step construction of N-substituted carbazoles by way of the Pd-catalyzed double N-arylation reaction of primary amines with 2,2′-dibromobiphenyl is described. Aryl and aliphatic amines including tert-butylamine and a protected glucopyranosylamine were effectively transformed into the corresponding N-substituted carbazoles. The first total synthesis of murrastifoline-A, a biscarbazole alkaloid, based on this methodology is also presented.",
keywords = "Double N-arylation, Murrastifoline-A, N-Substituted carbazole, One-pot synthesis",
author = "Takafumi Kitawaki and Yoko Hayashi and Akiko Ueno and Noritaka Chida",
note = "Funding Information: We thank Professor H. Furukawa (Meijo University, Nagoya, Japan) for providing us with spectral data of natural murrastifoline-A. We also thank Professor K. Nozaki (The University of Tokyo, Tokyo, Japan) for valuable discussions on the double N-arylation reaction. This work was partially supported by Grant-in-Aid for the 21st Century COE program {\textquoteleft}KEIO LCC{\textquoteright} from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.",
year = "2006",
month = jul,
day = "17",
doi = "10.1016/j.tet.2006.04.087",
language = "English",
volume = "62",
pages = "6792--6801",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "29",
}