One-step construction of carbazoles by way of the palladium-catalyzed double N-arylation reaction and its application to the total synthesis of murrastifoline-A

Takafumi Kitawaki, Yoko Hayashi, Akiko Ueno, Noritaka Chida

研究成果: Article

92 引用 (Scopus)

抜粋

The one-step construction of N-substituted carbazoles by way of the Pd-catalyzed double N-arylation reaction of primary amines with 2,2′-dibromobiphenyl is described. Aryl and aliphatic amines including tert-butylamine and a protected glucopyranosylamine were effectively transformed into the corresponding N-substituted carbazoles. The first total synthesis of murrastifoline-A, a biscarbazole alkaloid, based on this methodology is also presented.

元の言語English
ページ(範囲)6792-6801
ページ数10
ジャーナルTetrahedron
62
発行部数29
DOI
出版物ステータスPublished - 2006 7 17

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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