TY - GEN
T1 - One-Step Fabrication of Multi-Functional Core-Shell Janus Microparticles for Theranostics Application
AU - Tsuchiya, Mio
AU - Kurashina, Yuta
AU - Heo, Yun Jung
AU - Onoe, Hiroaki
N1 - Funding Information:
This work was partly supported by JKA and its promotion funds from KEIRIN RACE, JSPS Grant-in-Aid for Young Scientists (19K14920), Japan, and JSPS and NRF under the Japan-Korea Basic Scientific Cooperation Program.
Publisher Copyright:
© 2020 IEEE.
PY - 2020/1
Y1 - 2020/1
N2 - We present a one-step method to fabricate microparticles to detect substances and release drugs in our bodies. Our microparticles have two compartments and an outer shell. The two compartments (Janus cores) enable the encapsulation of different materials separately for diagnosis and therapy while the outer shell reduces the adhesion and protects the encapsulated materials. These multi-functional core-shell Janus microparticles are fabricated by simply ejecting pre-gel solutions into a calcium chloride solution under centrifugal gravity application and UV irradiation. Moreover, we implanted these microparticles in biological tissue and demonstrated the transdermal sensing and drug model release. We believe that our fabrication method and particle design could be an effective approach for multi-functional smart theranostic medicine.
AB - We present a one-step method to fabricate microparticles to detect substances and release drugs in our bodies. Our microparticles have two compartments and an outer shell. The two compartments (Janus cores) enable the encapsulation of different materials separately for diagnosis and therapy while the outer shell reduces the adhesion and protects the encapsulated materials. These multi-functional core-shell Janus microparticles are fabricated by simply ejecting pre-gel solutions into a calcium chloride solution under centrifugal gravity application and UV irradiation. Moreover, we implanted these microparticles in biological tissue and demonstrated the transdermal sensing and drug model release. We believe that our fabrication method and particle design could be an effective approach for multi-functional smart theranostic medicine.
UR - http://www.scopus.com/inward/record.url?scp=85083158539&partnerID=8YFLogxK
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U2 - 10.1109/MEMS46641.2020.9056399
DO - 10.1109/MEMS46641.2020.9056399
M3 - Conference contribution
AN - SCOPUS:85083158539
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 32
EP - 35
BT - 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Y2 - 18 January 2020 through 22 January 2020
ER -