One-Step Synthesis of Acylborons from Acyl Chlorides through Copper-Catalyzed Borylation with Polystyrene-Supported PPh3Ligand

Masataka Nakahara, Kazuki Kurahayashi, Kengo Hanaya, Takeshi Sugai, Shuhei Higashibayashi

研究成果: Article査読

抄録

We developed a one-step synthesis of acylborons from both readily available acyl chlorides and bis(pinacolato)diboron through copper(I)-catalyzed borylation. Under the reaction conditions using tBuOLi, polystyrene-supported triphenylphosphine as a copper ligand was found to promote the borylation of acyl chlorides while suppressing alcoholysis. This method enables the facile synthesis of potassium acyltrifluoroborates.

本文言語English
ページ(範囲)5596-5601
ページ数6
ジャーナルOrganic Letters
24
30
DOI
出版ステータスPublished - 2022 8月 5

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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