One-year eGFR decline rate is a good predictor of prognosis of renal failure in patients with type 2 diabetes

Jun Nojima, Shu Meguro, Naoto Ohkawa, Michiaki Furukoshi, Toshihide Kawai, Hiroshi Itoh

研究成果: Article査読

14 被引用数 (Scopus)

抄録

It is difficult to distinguish the onset of renal function decline from the typical variation in estimated glomerular filtration rate (eGFR) measurements in clinical practice. In this study, we used data analysis incorporating smoothing techniques to identify significant trends despite large amounts of noise. We identified the starting points of meaningful eGFR decline based on eGFR trajectories. This was a retrospective observational study of 2533 type 2 diabetes patients. We calculated 1-year eGFR decline rates from the difference between each eGFR value and that of the previous year. We examined the prediction capacity of 1-year eGFR decline rate for renal prognosis. When we performed receiver operating characteristic analysis, the area under the curve of 1-year eGFR decline rate was 0.963 (95% confidence interval: 0.953-0.973). With a cut-offvalue of more than 7.5% eGFR decline during a 1-year period, the sensitivity was 98.8% and specificity was 82.3%. The predictive accuracy of 1-year eGFR decline rate for renal prognosis was high.

本文言語English
ページ(範囲)746-754
ページ数9
ジャーナルProceedings of the Japan Academy Series B: Physical and Biological Sciences
93
9
DOI
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • 農業および生物科学(全般)
  • 物理学および天文学(全般)

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