Opioid modulation of vasopressin secretion in conscious rats

Takayuki Yamada, Kazuwa Nakao, Hiroshi Itoh, Gotaro Shirakami, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Narito Morii, Shozo Shiono, Hiroo Imura

研究成果: Article査読

5 被引用数 (Scopus)

抄録

To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

本文言語English
ページ(範囲)361-367
ページ数7
ジャーナルClinical and Experimental Hypertension
A10
S1
DOI
出版ステータスPublished - 1988
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 生理学

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