抄録
To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 361-367 |
| ページ数 | 7 |
| ジャーナル | Clinical and Experimental Hypertension |
| 巻 | A10 |
| 発行部数 | S1 |
| DOI | |
| 出版物ステータス | Published - 1988 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Internal Medicine
- Physiology
これを引用
Opioid modulation of vasopressin secretion in conscious rats. / Yamada, Takayuki; Nakao, Kazuwa; Itoh, Hiroshi; Shirakami, Gotaro; Sugawara, Akira; Saito, Yoshihiko; Mukoyama, Masashi; Arai, Hiroshi; Hosoda, Kiminori; Morii, Narito; Shiono, Shozo; Imura, Hiroo.
：: Clinical and Experimental Hypertension, 巻 A10, 番号 S1, 1988, p. 361-367.研究成果: Article
}
TY - JOUR
T1 - Opioid modulation of vasopressin secretion in conscious rats
AU - Yamada, Takayuki
AU - Nakao, Kazuwa
AU - Itoh, Hiroshi
AU - Shirakami, Gotaro
AU - Sugawara, Akira
AU - Saito, Yoshihiko
AU - Mukoyama, Masashi
AU - Arai, Hiroshi
AU - Hosoda, Kiminori
AU - Morii, Narito
AU - Shiono, Shozo
AU - Imura, Hiroo
PY - 1988
Y1 - 1988
N2 - To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.
AB - To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.
KW - Blood pressure
KW - Carbachol
KW - Heart rate
KW - Leumorphin
KW - Naloxone Nicotine
KW - Opioid peptide
KW - Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0024272783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024272783&partnerID=8YFLogxK
U2 - 10.3109/10641968809075991
DO - 10.3109/10641968809075991
M3 - Article
C2 - 3243002
AN - SCOPUS:0024272783
VL - A10
SP - 361
EP - 367
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 1064-1963
IS - S1
ER -