Optic nerve seeding of atypical meningiomas presenting with subacute visual loss: 2 case reports with genetic characterization

Yohei Kitamura, Takenori Akiyama, Hikaru Sasaki, Yuichiro Hayashi, Kazunari Yoshida

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical meningioma with high MIB-1 indices and p53-positive cell ratios in each case. Comparative genomic hybridization showed significant chromosomal copy number alterations similar to the results of previous surgeries, confirming that the tumors were disseminated lesions. The present findings suggest that genetic characteristics, such as 1p and 10qcen-23 losses and 17q and 20 gains, shared by the 2 cases might be associated with CSF dissemination of meningiomas.

本文言語English
ページ(範囲)494-498
ページ数5
ジャーナルJournal of neurosurgery
119
2
DOI
出版ステータスPublished - 2013 8月

ASJC Scopus subject areas

  • 外科
  • 臨床神経学

フィンガープリント

「Optic nerve seeding of atypical meningiomas presenting with subacute visual loss: 2 case reports with genetic characterization」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル