Optical scanning system for light-absorption measurement of deep biological tissue

Tsukasa Funane, Hirokazu Atsumori, Masashi Kiguchi, Yukari Tanikawa, Eiji Okada

    研究成果: Article査読

    3 被引用数 (Scopus)

    抄録

    A noncontact near-infrared scanning system for multi-distance absorption measurement of deep biological tissue was developed. An 808-nm laser, whose focal point on the surface of biological tissue is controlled by a galvano scanner, is used as a light source. A phosphor is placed at a detection focal point on the tissue surface. The light that propagates through tissue and exits from the tissue surface beneath the phosphor excites the phosphor. The fluorescence emitted from the phosphor is detected by an avalanche photodiode. The system is used to measure 20 points on tissue surface at which source-detector (S-D) distances are 7-45 mm (with 2-mm intervals). Neither the light source nor the detector contacts the tissue surface. The system was validated by using it to measure the absorption change of an absorber (which is embedded in a deep layer of a tissue-simulating phantom) while the surface-layer thickness of the phantom was changed from 1 to 12 mm. It was demonstrated that both the relative absorption change of the absorber and the absolute thickness of the surface layer can be estimated from the measured optical-density change (ΔOD) and the dependence of OD on S-D distance, respectively.

    本文言語English
    論文番号093101
    ジャーナルReview of Scientific Instruments
    82
    9
    DOI
    出版ステータスPublished - 2011 9 1

    ASJC Scopus subject areas

    • Instrumentation

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