TY - JOUR
T1 - Organ and brain crosstalk
T2 - The liver-brain axis in gastrointestinal, liver, and pancreatic diseases
AU - Matsubara, Yuta
AU - Kiyohara, Hiroki
AU - Teratani, Toshiaki
AU - Mikami, Yohei
AU - Kanai, Takanori
N1 - Funding Information:
This study was funded by the Japan Society for the Promotion of Science (JSPS) KAKENHI (B) 20H03666 to Y.M., and (A) 20H00536 to T.K.; JSPS Grant-in-Aid for Transformative Research Areas(B) : 21H05123 to YM.; Advanced Research and Development Programs for Medical Innovation (AMED-CREST; 16gm1010003h0001 and 21gm1510002h0001to T.K. and the Practical Research Project for Rare/Intractable Disease ; 21ek0109556h0001 to Y.M.); Takeda Science Foundation ; Kanae Foundation for The Promotion of Medical Science ; Mishima Kaiun Memorial Foundation Research Grant ; Yakult Bio-Science Foundation ; the Japan Foundation for Applied Enzymology ; and Keio University Medical Fund .The authors declared no conflicts of interest.
Funding Information:
This study was funded by the Japan Society for the Promotion of Science (JSPS) KAKENHI (B) 20H03666 to Y.M., and (A) 20H00536 to T.K.; JSPS Grant-in-Aid for Transformative Research Areas(B): 21H05123 to YM.; Advanced Research and Development Programs for Medical Innovation (AMED-CREST; 16gm1010003h0001 and 21gm1510002h0001to T.K. and the Practical Research Project for Rare/Intractable Disease; 21ek0109556h0001 to Y.M.); Takeda Science Foundation; Kanae Foundation for The Promotion of Medical Science; Mishima Kaiun Memorial Foundation Research Grant; Yakult Bio-Science Foundation; the Japan Foundation for Applied Enzymology; and Keio University Medical Fund.The authors declared no conflicts of interest.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/3/1
Y1 - 2022/3/1
N2 - The liver is the largest organ in the human body and is responsible for the metabolism and storage of the three principal nutrients: carbohydrates, fats, and proteins. In addition, the liver contributes to the breakdown and excretion of alcohol, medicinal agents, and toxic substances and the production and secretion of bile. In addition to its role as a metabolic centre, the liver has recently attracted attention for its function in the liver-brain axis, which interacts closely with the central nervous system via the autonomic nervous system, including the vagus nerve. The liver-brain axis influences the control of eating behaviour in the central nervous system through stimuli from the liver. Conversely, neural signals from the central nervous system influence glucose, lipid, and protein metabolism in the liver. The liver also receives a constant influx of nutrients and hormones from the intestinal tract and compounds of bacterial origin via the portal system. As a result, the intestinal tract and liver are involved in various immunological interactions. A good example is the co-occurrence of primary sclerosing cholangitis and ulcerative colitis. These heterogeneous roles of the liver-brain axis are mediated via the vagus nerve in an asymmetrical manner. In this review, we provide an overview of these interactions, mainly with the liver but also with the brain and gut.
AB - The liver is the largest organ in the human body and is responsible for the metabolism and storage of the three principal nutrients: carbohydrates, fats, and proteins. In addition, the liver contributes to the breakdown and excretion of alcohol, medicinal agents, and toxic substances and the production and secretion of bile. In addition to its role as a metabolic centre, the liver has recently attracted attention for its function in the liver-brain axis, which interacts closely with the central nervous system via the autonomic nervous system, including the vagus nerve. The liver-brain axis influences the control of eating behaviour in the central nervous system through stimuli from the liver. Conversely, neural signals from the central nervous system influence glucose, lipid, and protein metabolism in the liver. The liver also receives a constant influx of nutrients and hormones from the intestinal tract and compounds of bacterial origin via the portal system. As a result, the intestinal tract and liver are involved in various immunological interactions. A good example is the co-occurrence of primary sclerosing cholangitis and ulcerative colitis. These heterogeneous roles of the liver-brain axis are mediated via the vagus nerve in an asymmetrical manner. In this review, we provide an overview of these interactions, mainly with the liver but also with the brain and gut.
UR - http://www.scopus.com/inward/record.url?scp=85121593714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121593714&partnerID=8YFLogxK
U2 - 10.1016/j.neuropharm.2021.108915
DO - 10.1016/j.neuropharm.2021.108915
M3 - Review article
C2 - 34919906
AN - SCOPUS:85121593714
VL - 205
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
M1 - 108915
ER -