Organ preservation in the treatment of malignant solid tumors in children

M. Saeki, M. Nakano, T. Kuroda, T. Kinjo, M. Tori-Kai, Y. Tsunematsu, M. Kumagai, Y. Matsumoto, H. Masaki, E. Kohda

研究成果: Review article

1 引用 (Scopus)

抜粋

Organ preservation is one of the requirements for maintaining the high quality of life after the treatment of malignant solid tumors in children. We analyze our recent results of renal preservation in the abdominal neuroblastoma and describe 3 cases of successful organ preservation in pelvic malignancy. Between 1982 and 1996, 29 patients with adrenal or retroperitoneal neuroblastoma, that extended into the surrounding tissues and organs and/or to the contralateral side, underwent delayed primary excision. Before 1982, 9 patients were treated and only one ipsilateral kidney was preserved. On the other hand, 13 of 20 kidneys were preserved after 1987. Adoption of cisplatinum deepened our awareness of preserving the kidney. Furthermore, we have altered our strategy since 1987 to continuing preoperative chemotherapy until the size of the tumor becomes as small as it is estimated completely resectable by our own index, which is derived from computed tomography. Kidneys are shielded during intraoperative irradiation, and the tumor relapsed from the shielded area of retroperitoneum in one patient. Four of 14 preserved kidneys became atrophic and lost their function. The bladder and the rectum were left intact at tumor resection after intensive chemotherapy in two patients with pelvic (one retroperitoneal and one vaginal) rhabdomyosarcoma. A yolk sac tumor of the vagina responded completely to chemotherapy with cisplatinum, etoposide and bleomycin. The patient has survived 7.5 years without any local and distant relapse in spite of the fact that surgery, aside from several diagnostic biopsies, was not undertaken.

元の言語English
ページ(範囲)666-672
ページ数7
ジャーナルJapanese Journal of Cancer and Chemotherapy
24
発行部数6
出版物ステータスPublished - 1997 9 24
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント Organ preservation in the treatment of malignant solid tumors in children' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Saeki, M., Nakano, M., Kuroda, T., Kinjo, T., Tori-Kai, M., Tsunematsu, Y., Kumagai, M., Matsumoto, Y., Masaki, H., & Kohda, E. (1997). Organ preservation in the treatment of malignant solid tumors in children. Japanese Journal of Cancer and Chemotherapy, 24(6), 666-672.