Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: Diversification between the two species

H. Nomiyama, A. Mera, O. Ohneda, R. Miura, T. Suda, O. Yoshie

研究成果: Article

32 引用 (Scopus)

抜粋

Chemokines are a family of small cytokines that play essential roles in the directed migration of various types of leukocytes. Based on the arrangement of the conserved cysteine residues, they are classified into two major subfamilies, CXC and CC, and two minor subfamilies, C and CX3C. So far, more than 40 members of this family have been identified in humans. Strikingly, the majority of CXC chemokine genes and that of CC chemokine genes are closely clustered at chromosomes 4q12-21 and 17q11.2, respectively. Similarly, the mouse major CXC and CC chemokine gene clusters are located on chromosomes 5 and 11, respectively. In order to understand the evolutionary processes that generated large numbers of CXC and CC chemokine genes in the respective chromosomal sites, we have constructed BAC and YAC contigs covering the human and mouse major clusters of CXC and CC chemokine genes. The results reveal that the organizations of CXC and CC chemokine genes in the major clusters are quite diverged between the two species most probably due to very recent gene duplications and rearrangements. Our results provide an important insight into the evolutionary processes that generated the major chemokine gene clusters and also valuable information in assigning the orthologues between human and mouse major cluster chemokines.

元の言語English
ページ(範囲)110-113
ページ数4
ジャーナルGenes and Immunity
2
発行部数2
DOI
出版物ステータスPublished - 2001 4

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

フィンガープリント Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: Diversification between the two species' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用