抄録
The highly regioselective organocatalytic chlorosilylation of oxirane derivatives using bulky silyl reagents such as (tert-butyl)diphenylsilyl chloride (TBDPSCl) or triphenylsilyl chloride (Ph3SiCl) was developed. The reaction was effectively catalyzed with 4-methoxypyridine N-oxide in the presence of sodium sulfate (Na2SO4). Several silylated halohydrins were obtained with complete regioselectivity and the reaction was applied to the synthesis of carvedilol. (Figure presented.) .
本文言語 | English |
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ページ(範囲) | 1886-1891 |
ページ数 | 6 |
ジャーナル | Advanced Synthesis and Catalysis |
巻 | 358 |
号 | 12 |
DOI | |
出版ステータス | Published - 2016 |
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry