Organocatalytic Regioselective Chlorosilylation of Oxirane Derivatives: Mild and Effective Insertion of Bulky Silyl Chloride by Using 4-Methoxypyridine N-Oxide

Keisuke Yoshida, Hina Suzuki, Hiroki Inoue, Kohei Matsui, Yuta Fujino, Yohei Kanoko, Yukihiro Itatsu, Ken Ichi Takao

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The highly regioselective organocatalytic chlorosilylation of oxirane derivatives using bulky silyl reagents such as (tert-butyl)diphenylsilyl chloride (TBDPSCl) or triphenylsilyl chloride (Ph3SiCl) was developed. The reaction was effectively catalyzed with 4-methoxypyridine N-oxide in the presence of sodium sulfate (Na2SO4). Several silylated halohydrins were obtained with complete regioselectivity and the reaction was applied to the synthesis of carvedilol. (Figure presented.) .

本文言語English
ページ(範囲)1886-1891
ページ数6
ジャーナルAdvanced Synthesis and Catalysis
358
12
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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