Orphan receptors COUP-TF and DAX-1 as targets in disordered CYP17 expression in adrenocortical tumors

H. Shibata, Y. Ikeda, K. Morohashi, T. Mukai, I. Kurihara, T. Ando, T. Suzuki, S. Kobayashi, K. Hayashi, M. Hayashi, I. Saito, T. Saruta

研究成果: Article

12 引用 (Scopus)

抜粋

CYP17 gene transcription is activated by SF-1 binding to a cyclic AMP-responsive sequence within the promoter region of the gene, and its transcription is inhibited by COUP-TF binding to the sequence. Another orphan receptor, DAX-1, is shown to act as a suppressor of SF-1-mediated transcription. We examined the expression level of these orphan receptors in adrenocortical tumors and compared the results with CYP17 expression. CYP17 was highly expressed in cortisol-producing adenomas, whereas COUP-TF and DAX-1 expression levels were very low. In deoxycorticosterone-producing adenomas, on the other hand, CYP17 expression was extremely low, whereas DAX-1 was highly expressed and SF-1 expression was slightly decreased. In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.

元の言語English
ページ(範囲)1039-1044
ページ数6
ジャーナルEndocrine Research
26
発行部数4
DOI
出版物ステータスPublished - 2000 1 1

ASJC Scopus subject areas

  • Endocrinology

フィンガープリント Orphan receptors COUP-TF and DAX-1 as targets in disordered CYP17 expression in adrenocortical tumors' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Shibata, H., Ikeda, Y., Morohashi, K., Mukai, T., Kurihara, I., Ando, T., Suzuki, T., Kobayashi, S., Hayashi, K., Hayashi, M., Saito, I., & Saruta, T. (2000). Orphan receptors COUP-TF and DAX-1 as targets in disordered CYP17 expression in adrenocortical tumors. Endocrine Research, 26(4), 1039-1044. https://doi.org/10.3109/07435800009048636