Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

T. H. Kuo; T. Kubota; M. Watanabe; T. Furukawa; S. Kase; H. Tanino; H. Nishibori; Yoshirou Saikawa; T. Teramoto; K. Ihsibiki; M. Kitajima; R. M. Hoffman

Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

T. H. Kuo, T. Kubota, M. Watanabe, T. Furukawa, S. Kase, H. Tanino, H. Nishibori, Yoshirou Saikawa, T. Teramoto, K. Ihsibiki, M. Kitajima, R. M. Hoffman

法務研究科(法科大学院)

研究成果: Article › 査読

30 被引用数 (Scopus)

抄録

We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 10⁶ tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

本文言語	English
ページ（範囲）	1407-1410
ページ数	4
ジャーナル	Anticancer research
巻	12
号	5
出版ステータス	Published - 1992 1 1

ASJC Scopus subject areas

Oncology
Cancer Research

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引用スタイル

Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice. / Kuo, T. H.; Kubota, T.; Watanabe, M.; Furukawa, T.; Kase, S.; Tanino, H.; Nishibori, H.; Saikawa, Yoshirou; Teramoto, T.; Ihsibiki, K.; Kitajima, M.; Hoffman, R. M.

In: Anticancer research, Vol. 12, No. 5, 01.01.1992, p. 1407-1410.

研究成果: Article › 査読

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abstract = "We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.",

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AU - Kuo, T. H.

AU - Kubota, T.

AU - Watanabe, M.

AU - Furukawa, T.

AU - Kase, S.

AU - Tanino, H.

AU - Nishibori, H.

AU - Saikawa, Yoshirou

AU - Teramoto, T.

AU - Ihsibiki, K.

AU - Kitajima, M.

AU - Hoffman, R. M.

PY - 1992/1/1

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N2 - We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

AB - We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

KW - Orthotopic reconstitution

KW - SCID mouse

KW - Small-cell lung carcinoma

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