Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

T. H. Kuo, T. Kubota, M. Watanabe, T. Furukawa, S. Kase, H. Tanino, H. Nishibori, Yoshirou Saikawa, T. Teramoto, K. Ihsibiki, M. Kitajima, R. M. Hoffman

研究成果: Article査読

30 被引用数 (Scopus)

抄録

We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 X 106 tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

本文言語English
ページ(範囲)1407-1410
ページ数4
ジャーナルAnticancer research
12
5
出版ステータスPublished - 1992 1月 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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