Osteoporosis associated with rheumatoid arthritis

Hideto Kameda, Tsutomu Takeuchi

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Patients with rheumatoid arthritis(RA) develop both generalized and periarticular osteoporosis. Both of them are believed to be associated with increased production of inflammatory cytokines(TNF alpha, IL-1 beta, IL-6) and increased formation and activation of osteoclasts. Whether glucocorticoids work positively or negatively on generalized/periarticular osteoporosis is still controversial. RANKL has been shown to be expressed on T cells and fibroblast-like cells in the synovium, thus 'RANKL-RANK' pathway is likely to play an important role in periarticular osteoporosis and bone erosion as well as generalized osteoporosis. Among various therapies for generalized/periarticular osteoporosis in RA, anti-cytokine antibodies/antagonists and osteoclast inhibitors including bisphosphonates are promising.

本文言語English
ページ(範囲)292-298
ページ数7
ジャーナルNippon rinsho. Japanese journal of clinical medicine
61
2
出版ステータスPublished - 2003 2
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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