Outer retinal assessment using spectral-domain optical coherence tomography in patients with Alzheimer’s and Parkinson’s disease

Atsuro Uchida, Jagan A. Pillai, Robert Bermel, Aaron Bonner-Jackson, Alexander Rae-Grant, Hubert Fernandez, James Bena, Stephen E. Jones, James B. Leverenz, Sunil K. Srivastava, Justis P. Ehlers

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PURPOSE. To investigate outer retinal parameters among patients with various chronic neurodegenerative disorders by using spectral-domain coherence tomography (OCT) in a prospective cross-sectional cohort study. METHODS. A total of 132 participants were enrolled following a comprehensive diagnostic evaluation with neurologic, neuropsychology, and magnetic resonance imaging volumetric evaluations. Participants were 50 years or older, either diagnosed with Alzheimer’s disease (AD) dementia, amnestic mild cognitive impairment (MCI), non-AD dementia, Parkinson’s disease (PD), or age-and sex-matched controls. All participants underwent a macular cube scan for both eyes by using the Cirrus 4000 HD-OCT (Zeiss, Oberkochen, Germany). The OCT image with the best quality was selected for further analysis. Outer retinal parameters including ellipsoid zone mapping and outer nuclear layer metrics were evaluated with a novel software platform. RESULTS. One hundred twenty-four eyes of 124 participants with AD dementia (24 eyes), amnestic MCI (22 eyes), non-AD dementia (20 eyes), PD (22 eyes), and age-and sex-matched controls (36 eyes) were included in the analysis. Eight eyes were excluded either due to the presence of macular disease or poor quality of the OCT image. The mean ages of participants were 65.9 ± 8.9 years. The outer retinal thickness measures did not show any statistical significance between the groups. However, ellipsoid zone to retinal pigment epithelium volume correlated with cognitive testing scores in all study participants. CONCLUSIONS. There were no identifiable differences in the outer retinal metrics across neurodegenerative disease groups and controls. The relationship between the degree of cognitive impairment and ellipsoid zone to retinal pigment epithelium volume warrants further study.

元の言語English
ページ(範囲)2768-2777
ページ数10
ジャーナルInvestigative Ophthalmology and Visual Science
59
発行部数7
DOI
出版物ステータスPublished - 2018 6
外部発表Yes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Uchida, A., Pillai, J. A., Bermel, R., Bonner-Jackson, A., Rae-Grant, A., Fernandez, H., Bena, J., Jones, S. E., Leverenz, J. B., Srivastava, S. K., & Ehlers, J. P. (2018). Outer retinal assessment using spectral-domain optical coherence tomography in patients with Alzheimer’s and Parkinson’s disease. Investigative Ophthalmology and Visual Science, 59(7), 2768-2777. https://doi.org/10.1167/iovs.17-23240