Overexpression of KIT in chromophobe renal cell carcinoma

Ken Yamazaki, Michiie Sakamoto, Tsutomu Ohta, Yae Kanai, Misao Ohki, Setsuo Hirohashi

研究成果: Article査読

135 被引用数 (Scopus)

抄録

We analysed gene-expression profiles in 15 surgical specimens of conventional, papillary, and chromophobe renal cell carcinomas (RCCs) using high-density oligonucleotide arrays. From about 12 000 genes targeted by the array, 67 were upregulated specifically in each histological type of RCC. The oncogene KIT was one of the genes whose expression was upregulated specifically in chromophobe RCCs. Immunohistochemical analysis demonstrated the KIT gene product on the cell membrane of chromophobe RCC in all cases, although it was not detected in conventional RCCs or non-neoplastic kidneys except for weak staining in the cytoplasm of renal tubules. These results suggest that each histological subtype of RCC has a unique gene-expression profile, and in particular indicates for the first time that KIT could be a useful marker for chromophobe RCC. As overexpression of KIT might be involved in tumor growth, KIT could be a new therapeutic target in this special type of RCC.

本文言語English
ページ(範囲)847-852
ページ数6
ジャーナルOncogene
22
6
DOI
出版ステータスPublished - 2003 2 13

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 癌研究

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