The Pd-peroxo complex (dioxygen)bis(triphenyIphosphine)palladium [Pd(Ph3P)202] caused epoxidation of olefins and oxidations of sulfides and sulfoxides in the presence of carboxylic acid derivatives. The Co-superoxo complex cobalt bis(salicylaldehyde)-3,3/ -diamino-di-n-propylamine [Co(Salpr)02] also oxidized sulfides to sulfoxides during the reaction with carboxylic acid derivatives. These oxidations were dependent upon the presence of a metal-dioxygen complex and an electrophile such as acyl cation. Metal-acylperoxide, generated in situ by the reaction of metal-dioxygen complex with a carboxylic acid derivative, could promote heterolytic cleavage of the 0–0 bond of dioxygen coordinated to metal to form a metal-oxo complex, which seems to be the ultimate species mediating the oxidations.
ASJC Scopus subject areas
- Drug Discovery