Oxidative stress in the RPE and its contribution to AMD pathogenesis: Implication of light exposure

Yoko Ozawa

研究成果: Chapter

3 被引用数 (Scopus)

抄録

The retinal pigment epithelium (RPE) is a single layer of cuboidal cells that develops from the neural tube as well as neural retina does, and is therefore considered part of the central nervous system. While the neural retina receives light and converts it to electrical signals to process information and transfer it to the brain, the RPE acts as an essential coordinator of the retinal microenvironment for appropriate retinal neural function. Reactive oxygen species (ROS) are generated during basal cellular metabolic processes. Moreover, daily exposure to light stimuli enhances the production of ROS in the RPE and the neural retina, the excessive accumulation of which contributes to retinal pathogenesis. In this section, oxidative stress in the RPE and its proposed contribution to age-related macular degeneration (AMD) are discussed, reviewing recent in vivo and in vitro studies that support the role of oxidative stress in the development and progression of AMD.

本文言語English
ホスト出版物のタイトルNeuroprotection and Neuroregeneration for Retinal Diseases
出版社Springer Japan
ページ239-253
ページ数15
ISBN(電子版)9784431549659
ISBN(印刷版)4431549641, 9784431549642
DOI
出版ステータスPublished - 2014 5月 1

ASJC Scopus subject areas

  • 医学(全般)

フィンガープリント

「Oxidative stress in the RPE and its contribution to AMD pathogenesis: Implication of light exposure」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル