Oxygenation of nucleosides by peroxide adduct of binuclear iron(III) complex with a μ-oxo bridge

Sayo Ito, Yumiko Sasaki, Yasuyuki Takahashi, Shigeru Ohba, Yuzo Nishida

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The (μ-oxo)(μ-carbonato)diiron(III) complex with H2(tfda) (H2(tfda) = 2-aminomethyl-tetrahydrofuran-N,N-diacetic acid) exhibited high activity for hydroxylation of 2'-deoxyguanosine in the presence of hydrogen peroxide, giving 8-hydroxydeoxyguanosine, but its hydroxylation activity towards other nucleosides such as 2'-deoxyadenosine, adenosine or thymidine was found negligible. In the case of the Fe(III)-(eda) complex (H2(eda) = 2-methoxyethylamine-N,N-diacetic acid), hydroxylation occurred mainly at the sugar site, converting 2'-deoxyguanosine to guanosine. Based on the spectroscopic and structural properties of these iron(III) compounds, it seems most likely that an intrinsic active species for hydroxylation should be an electrophilic peroxide adduct of the (μ-oxo)diiron(III) core with η1-coordination mode, while the contribution of OH· to the hydroxylation reaction of nucleosides is ruled out.

本文言語English
ページ(範囲)554-561
ページ数8
ジャーナルZeitschrift fur Naturforschung - Section C Journal of Biosciences
54
7-8
DOI
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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