p59fyn-p125FAK cooperation in Development of CD4+CD8+ Thymocytes

Satoshi Kanazawa, Duško Ilić, Motohiro Hashiyama, Tetsuo Noumura, Tadashi Yamamoto, Toshio Suda, Shinichi Aizawa

研究成果: Article

24 被引用数 (Scopus)

抄録

p59fyn is an Src family nonreceptor tyrosine kinase that has been suggested to play an important role in T-cell development and function. p125FAK is a unique nonreceptor tyrosine kinase and has been known to respond to integrin-extracellular matrix interactions. To examine their roles in thymocytes, heterozygous fak mutation was introduced into homozygous Fyn deficiency. The double mutation, but neither Fyn deficiency nor FAK heterozygosity alone, displayed impaired development of CD4+CD8+ thymocytes with atrophy of the thymic cortex, suggesting a unique cooperation between P59fyn and p125FAK in CD4+CD8+ T-cell development.

本文言語English
ページ(範囲)865-870
ページ数6
ジャーナルBlood
87
3
DOI
出版ステータスPublished - 1996 2 1

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

フィンガープリント 「p59<sup>fyn</sup>-p125<sup>FAK</sup> cooperation in Development of CD4<sup>+</sup>CD8<sup>+</sup> Thymocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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