Palladium-Catalyzed ortho-Selective C-H Chlorination of Benzamide Derivatives under Anodic Oxidation Conditions

Miki Konishi, Kazuya Tsuchida, Katsuya Sano, Takuya Kochi, Fumitoshi Kakiuchi

研究成果: Article査読

58 被引用数 (Scopus)

抄録

The palladium-catalyzed ortho-selective chlorination of N-quinolinylbenzamide derivatives with hydrochloric acid was achieved under anodic oxidation conditions. The use of 5,7-dichloro-8-quinolinyl group as directing group was effective for the selective chlorination, and the reaction was applicable to benzamide derivatives bearing various functional groups. Synthesis of vismodegib was also completed using the palladium-catalyzed electrochemical C-H chlorination in two different steps.

本文言語English
ページ(範囲)8716-8724
ページ数9
ジャーナルJournal of Organic Chemistry
82
16
DOI
出版ステータスPublished - 2017 8月 18

ASJC Scopus subject areas

  • 有機化学

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