Palladium-Catalyzed ortho-Selective C-H Chlorination of Benzamide Derivatives under Anodic Oxidation Conditions

Miki Konishi, Kazuya Tsuchida, Katsuya Sano, Takuya Kochi, Fumitoshi Kakiuchi

研究成果: Article

34 引用 (Scopus)

抄録

The palladium-catalyzed ortho-selective chlorination of N-quinolinylbenzamide derivatives with hydrochloric acid was achieved under anodic oxidation conditions. The use of 5,7-dichloro-8-quinolinyl group as directing group was effective for the selective chlorination, and the reaction was applicable to benzamide derivatives bearing various functional groups. Synthesis of vismodegib was also completed using the palladium-catalyzed electrochemical C-H chlorination in two different steps.

元の言語English
ページ(範囲)8716-8724
ページ数9
ジャーナルJournal of Organic Chemistry
82
発行部数16
DOI
出版物ステータスPublished - 2017 8 18

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Chlorination
Anodic oxidation
Palladium
Derivatives
HhAntag691
Bearings (structural)
Hydrochloric Acid
Functional groups
benzamide

ASJC Scopus subject areas

  • Organic Chemistry

これを引用

Palladium-Catalyzed ortho-Selective C-H Chlorination of Benzamide Derivatives under Anodic Oxidation Conditions. / Konishi, Miki; Tsuchida, Kazuya; Sano, Katsuya; Kochi, Takuya; Kakiuchi, Fumitoshi.

:: Journal of Organic Chemistry, 巻 82, 番号 16, 18.08.2017, p. 8716-8724.

研究成果: Article

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