Pancreas fat and β cell mass in humans with and without diabetes: An analysis in the Japanese population

Rie Murakami, Yoshifumi Saisho, Yuusuke Watanabe, Jun Inaishi, Tami Tsuchiya, Kinsei Kou, Seiji Sato, Minoru Kitago, Yuko Kitagawa, Taketo Yamada, Hiroshi Itoh

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Context: The mechanisms by which b cell mass is reduced in patients with type 2 diabetes remain unclear. It has been postulated that ectopic fat deposits in the pancreas induce b cell apoptosis, leading to the development of diabetes. Objective: The aim of this study was to clarify the effects of intrapancreatic fat on b and a cell mass in humans with and without diabetes. Design and Subjects: Using our tissue database, pancreas sections of 72 Japanese nondiabetic (NDM) autopsy cases and 50 diabetic and 49 age- and body mass index (BMI)-matched NDM patients who underwent pancreatic surgery were analyzed. In addition to histological grading, intrapancreatic fat area (IPFA) was quantified as fractional intralobular, but not interlobular, fat area to the whole pancreas area. Results: Although IPFA was positively correlated with age and BMI, there was no significant difference in IPFA between cases with and without diabetes. Moreover, no association was found between IPFA and either b or a cell area, or glycated hemoglobin. Conclusion: These findings suggest that pancreatic fat deposits have little effect on b cell mass and the development of diabetes in humans.

本文言語English
ページ(範囲)3251-3260
ページ数10
ジャーナルJournal of Clinical Endocrinology and Metabolism
102
9
DOI
出版ステータスPublished - 2017 9月 1

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学

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