Papillary thyroid carcinoma without metastases manifesting as an autonomously functioning thyroid nodule

Takafumi Majima, Kentaro Doi, Yasato Komatsu, Hiroshi Itoh, Atsushi Fukao, Michika Shigemoto, Chieko Takagi, Jerry Corners, Naomi Mizuta, Ryohei Kato, Kazuwa Nakao

研究成果: Article査読

29 被引用数 (Scopus)

抄録

A 59-year-old woman with papillary thyroid carcinoma inside of an autonomously functioning thyroid nodule is described in this report. The patient was referred to our clinic because of rapid weight loss and swelling on the left side of the neck. Ultrasonography of the thyroid demonstrated a nonhomogeneous nodule in the lower part of an enlarged left lobe. Both 99mTc and 123I thyroid scintigraphic imaging showed a hot area corresponding to the nodule with lower uptake in the remaining thyroid tissue. Histopathological examination of the nodule revealed papillary adenocarcinoma, and the immunohistochemistry proved weak but positive staining for triiodothyronine and thyroxine. Based on these findings, the nodule was diagnosed as a functioning papillary adenocarcinoma. Although thyroid carcinoma manifesting as a hot nodule on the radionuclide isotope scan is an extremely rare occurrence, the current case is clinically important because it suggests that the diagnosis of a hot nodule cannot always rule out thyroid carcinoma in the nodule, and that even a hot nodule requires careful management so that the malignancy is not overlooked.

本文言語English
ページ(範囲)309-316
ページ数8
ジャーナルEndocrine journal
52
3
DOI
出版ステータスPublished - 2005 6月
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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