Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Tomihisa Ohta, Takuro Maruyama, Minoru Nagahashi, Yasuyo Miyamoto, Shinzo Hosoi, Fumiyuki Kiuchi, Yasushi Yamazoe, Sachiko Tsukamoto

研究成果: Article

43 引用 (Scopus)

抜粋

A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

元の言語English
ページ(範囲)6631-6635
ページ数5
ジャーナルTetrahedron
58
発行部数33
DOI
出版物ステータスPublished - 2002 8 12
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • これを引用

    Ohta, T., Maruyama, T., Nagahashi, M., Miyamoto, Y., Hosoi, S., Kiuchi, F., Yamazoe, Y., & Tsukamoto, S. (2002). Paradisin C: A new CYP3A4 inhibitor from grapefruit juice. Tetrahedron, 58(33), 6631-6635. https://doi.org/10.1016/S0040-4020(02)00739-1