Paraneoplastic pemphigus associated with Castleman's disease and asymptomatic bronchiolitis obliterans

Wataru Fujimoto, Arihiko Kanehiro, Kazue Kuwamoto-Hara, Mari Saitoh, Takashi Nakakita, Masayuki Amagai, Jirô Arata, Keiji Iwatsuki

研究成果: Article査読

21 被引用数 (Scopus)

抄録

We describe a 19-year-old male patient who presented with recalcitrant erosions limited to the orolabial and genital mucosa for 18 months. The clinicopathologic diagnosis of paraneoplastic pemphigus was confirmed by indirect immunofluorescence staining of murine bladder epithelium, and the presence of IgG autoantibodies against envoplakin, periplakin, and 170 kDa protein. Enzyme-linked immunosorbent assay (ELISA) with desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1) recombinant proteins showed that the patient's sera were positive against Dsg3. Castleman's tumour was found in the pelvic cavity and resected completely. The orogenital erosions disappeared slowly after the resection of Castleman's tumour with the concomitant decrease in intercellular antibody titre and index values of Dsg ELISA. Although the patient was unaware of dyspnea on excertion, a notable air flow obstruction persisted over 17 months. The expiratory images of high resolution computed tomography showed air trapping, indicating the presence of asymptomatic but gradually progressive bronchiolitis obliterans.

本文言語English
ページ(範囲)355-359
ページ数5
ジャーナルEuropean Journal of Dermatology
12
4
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 皮膚病学

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