Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production

Masaharu Akiyama, Masayoshi Yamaoka, Yoko Mikami-Terao, Kentaro Yokoi, Takashi Inoue, Tomomasa Hiramatsu, Shuichi Ashizuka, Jyoji Yoshizawa, Hiroaki Katagi, Masahiro Ikegami, Hiroyuki Ida, Atsuko Nakazawa, Hajime Okita, Kenji Matsumoto

研究成果: Article査読

10 被引用数 (Scopus)

抄録

We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH.

本文言語English
ページ(範囲)554-559
ページ数6
ジャーナルJournal of Pediatric Hematology/Oncology
37
7
DOI
出版ステータスPublished - 2015 10月 1
外部発表はい

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学

フィンガープリント

「Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル