Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Koki Fujimori, Junpei Takaki, Yukari Shigemoto-Mogami, Yuko Sekino, Takeshi Suzuki, Kaoru Sato

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

本文言語English
ページ(範囲)145-149
ページ数5
ジャーナルJournal of Pharmacological Sciences
127
1
DOI
出版ステータスPublished - 2015 1

ASJC Scopus subject areas

  • 分子医療
  • 薬理学

フィンガープリント

「Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル