PARP-1 regulates expression of TGF-β receptors in T cells

Pin Zhang, Hiroko Nakatsukasa, Eric Tu, Shimpei Kasagi, Kairong Cui, Masaki Ishikawa, Joanne E. Konkel, Takashi Maruyama, Gang Wei, Brittany Abbatiello, Zhao Qi Wang, Keji Zhao, Wan Jun Chen

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Transforming growth factor-b (TGF-b) receptors (TbRs) are essential components for TGF-b signal transduction in T cells, yet the mechanisms by which the receptors are regulated remain poorly understood. We show here that Poly(ADP-ribose) polymerase-1 (PARP-1) regulates TGF-b receptor I (TbRI) and II (TbRII) expression in CD4+ T cells and subsequently affects Smad2/3-mediated TGF-b signal transduction. Inhibition of PARP-1 led to the upregulation of both TbRI and TbRII, yet the underlying molecular mechanisms were distinct. PARP-1 selectively bound to the promoter of TbRII, whereas the enzymatic activity of PARP-1 was responsible for the inhibition of TbRI expression. Importantly, inhibition of PARP-1 also enhanced expression of TbRs in human CD4+ T cells. Thus, PARP-1 regulates TbR expression and TGF-b signaling in T cells.

本文言語English
ページ(範囲)2224-2232
ページ数9
ジャーナルBlood
122
13
DOI
出版ステータスPublished - 2013
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

フィンガープリント

「PARP-1 regulates expression of TGF-β receptors in T cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル