Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease: The Ophelia syndrome

Toshiya Shinohara, Hideaki Kojima, Nishio Nakamura, Akihiko Ogata, Tomoko Betsuyaku, Akihiko Suzuki, Youichi Maki, Kazuo Nagashima

研究成果: Article査読

19 被引用数 (Scopus)

抄録

An archive autopsy case of a 50-year-old man who died of Hodgkin's lymphoma had a 4-year, 4-month history of dementia. After radiochemotherapy, the lymphoma subsided except for involvement of the spleen, but the dementia remained. Neuropathological examination revealed that the pathology was confined to the hippocampus, both hippocampi showing sclerosis without inflammation. Neurons of sector cornu ammonis (CA) 1 were completely lost whereas moderate neuron loss was also observed in sectors CA3 and 4, and the dentate gyrus. Neurons of sector CA2 were relatively well preserved and the subiculum was intact. There was no evidence of global hypoxia, or of neurodegenerative disorders with pathological changes affecting the hippocampus. Although there was a long preneoplastic history, and no inflammatory changes were found at autopsy, the present case of hippocampal sclerosis could be included in the category of paraneoplastic limbic encephalitis associated with Hodgkin's lymphoma or the Ophelia syndrome.

本文言語English
ページ(範囲)353-360
ページ数8
ジャーナルNeuropathology
25
4
DOI
出版ステータスPublished - 2005 12月

ASJC Scopus subject areas

  • 病理学および法医学
  • 臨床神経学

フィンガープリント

「Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease: The Ophelia syndrome」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル