PBSC collection from family donors in Japan: A prospective survey

Y. Kodera, K. Yamamoto, M. Harada, Y. Morishima, H. Dohy, S. Asano, Y. Ikeda, T. Nakahata, M. Imamura, K. Kawa, S. Kato, M. Tanimoto, Y. Kanda, R. Tanosaki, S. Shiobara, S. W. Kim, K. Nagafuji, M. Hino, K. Miyamura, R. SuzukiN. Hamajima, M. Fukushima, A. Tamakoshi, J. Halter, N. Schmitz, D. Niederwieser, A. Gratwohl

研究成果: Article査読

26 被引用数 (Scopus)


Severe adverse events (SAE) and late hematological malignancies have been reported after PBSC donation. No prospective data on incidence and risk factors have been available for family donors so far. The Japan Society for Hematopoietic Cell Transplantation (JSHCT) introduced therefore in 2000 a mandatory registration system. It defined standards for donor eligibility and asked harvest centers to report any SAE immediately. All donors were examined at day 30 and were to be contacted once each year for a period of 5 years. Acute SAEs within day 30 were reported from 47/3264 donations (1.44%) with 14 events considered as unexpected and severe (0.58%). No donor died within 30 days. Late SAEs were reported from 39/1708 donors (2.3%). The incidence of acute SAEs was significantly higher among donors not matching the JSHCT standards (P=0.0023). Late hematological malignancies in PBSC donors were not different compared with a retrospective cohort of BM donors (N:1/1708 vs N:2/5921; P=0.53). In conclusion, acute and late SAEs do occur in PBSC donors at relatively low frequency but risk factors can be defined.

ジャーナルBone Marrow Transplantation
出版ステータスPublished - 2014 2月

ASJC Scopus subject areas

  • 血液学
  • 移植


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