PD-1 deficiency results in the development of fatal myocarditis in MRL mice

Jian Wang, Il Mi Okazaki, Taku Yoshida, Shunsuke Chikuma, Yu Kato, Fumio Nakaki, Hiroshi Hiai, Tasuku Honjo, Taku Okazaki

研究成果: Article

89 引用 (Scopus)


The deficiency of programmed cell death 1 (PD-1, Pdcd1), a negative immuno-receptor belonging to the CD28/cytotoxic T lymphocyte antigen 4 (CTLA-4) family, can support various tissue-specific autoimmune conditions. Here, we analyzed the effect of PD-1 deficiency in MRL mice that is genetically predisposed to systemic autoimmunity. MRL-Pdcd1-/- mice developed a fatal myocarditis, which is reminiscent of CTLA-4-deficient (Ctla4-/-) mice. Massive infiltration of CD4+ and CD8+ T cells and myeloid cells was found in hearts of MRL-Pdcd1-/- mice concomitant with the production of high-titer auto-antibodies against cardiac myosin. In contrast to Ctla4-/- mice in which most of the CD4+ T cells are non-specifically activated and invade various organs, T cells in the heart but not in the spleen and lymph nodes are activated in MRL-Pdcd1-/- mice, suggesting that myocarditis is mediated by antigen-specific autoimmune response. Heart infiltrating myeloid cells strongly suppressed the allogenic response of T cells in vitro, suggesting that these Mac1+Gr1+ myeloid cells are phenotypically similar to myeloid suppressor cells, which can be found in tumorbearing hosts. These findings unravel the hidden heart-specific autoimmune predisposition of MRL mice and provide MRL-Pdcd1-/- mice as a useful animal model of lymphocytic myocarditis.

ジャーナルInternational immunology
出版物ステータスPublished - 2010 4 21

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Wang, J., Okazaki, I. M., Yoshida, T., Chikuma, S., Kato, Y., Nakaki, F., Hiai, H., Honjo, T., & Okazaki, T. (2010). PD-1 deficiency results in the development of fatal myocarditis in MRL mice. International immunology, 22(6), 443-452. https://doi.org/10.1093/intimm/dxq026