Pd-catalyzed Regio- A nd Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin

Akihiro Sugawara, Hirokazu Takada, Tomoyasu Hirose, Aoi Kimishima, Takeshi Yamada, Masaki Toda, Toru Kojima, Takanori Matsumaru, Toshiaki Sunazuka

研究成果: Article査読

抄録

Regio- A nd stereoselective hydrostannylation of alkyl ethynyl ethers generates alkenyl ethers, which are useful building blocks in organic synthesis. This efficient synthetic method, however, is limited. Here, we report not only an efficient method for a highly regio- A nd stereoselective Pd-catalyzed hydrostannylation of alkyl ethynyl ethers but also a scalable synthesis and construction of the core framework of luminamicin possessing all functional groups and stereocenters.

本文言語English
ページ(範囲)1758-1763
ページ数6
ジャーナルOrganic Letters
23
5
DOI
出版ステータスPublished - 2021 3 5
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

フィンガープリント

「Pd-catalyzed Regio- A nd Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル