Pemphigus vulgaris and its active disease mouse model

研究成果: Chapter

22 被引用数 (Scopus)

抄録

Pemphigus is an autoimmune disease of the skin and mucous membranes and is mediated by IgG autoantibodies against desmoglein (Dsg), a cadherin-type cell-cell adhesion molecule in desmosomes. Recently, an active disease mouse model of pemphigus vulgaris (PV) was generated with a unique approach using autoantigen knockout mice, in which selftolerance of the defective gene product is not acquired. This approach included the adoptive transfer of Dsg3-/- lymphocytes to Rag2-/- immunodeficient mice that express Dsg3- induced stable production of pathogenic anti-Dsg3 IgG for over 6 months and the phenotype of PV including oral erosion with the typical histology in recipient mice. Subsequently, AK and NAK series of anti-Dsg3 IgG monoclonal antibodies were developed from the PV model mice. These monoclonal antibodies showed pathogenic heterogeneity in blister formation, which is, at least in part, explained by their epitopes, and synergistic pathogenic effects by combining several monoclonal antibodies reacting in different parts of the molecule. Although this model does not reflect the actual triggers of autoimmune diseases, it does provide a means to investigate the roles of T and B lymphocytes in perpetuating autoantibody production and to clarify unsolved immunological mechanisms in the autoimmune diseases.

本文言語English
ホスト出版物のタイトルDermatologic Immunity
編集者Brian Nickoloff, Frank Nestle
ページ167-181
ページ数15
DOI
出版ステータスPublished - 2008 8月 21

出版物シリーズ

名前Current Directions in Autoimmunity
10
ISSN(印刷版)1422-2132
ISSN(電子版)1662-2936

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 生化学、遺伝学、分子生物学(全般)

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