Pemphigus vulgaris antigen is a desmosomal desmoglein

S. Kárpáti, M. Amagai, R. Prussick, J. R. Stanley

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Because pemphigus vulgaris antigen (PVA) is homologous to desmogleins which are in desmosomes, we asked whether PVA is also localized to desmosomes. Immunogold electron microscopy was used to localize binding of PV antibodies. Rabbit antibodies raised against fusion proteins containing the extracellular portion of PVA bound to desmosomes of cultured keratinocytes. PV patient serum affinity-purified on one of these fusion proteins and injected into neonatal mice localized to separating desmosomes. These results show that PVA belongs to the desmoglein subfamily of cadherins according to sequence, localization and, presumably, function.

本文言語English
ページ(範囲)24-26
ページ数3
ジャーナルDermatology
189
DOI
出版ステータスPublished - 1994 1 1
外部発表はい

ASJC Scopus subject areas

  • 皮膚病学

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