Peptide Toxins Targeting KV Channels

Kazuki Matsumura, Mariko Yokogawa, Masanori Osawa

研究成果: Chapter

抄録

A number of peptide toxins isolated from animals target potassium ion (K+) channels. Many of them are particularly known to inhibit voltage-gated K+ (KV) channels and are mainly classified into pore-blocking toxins or gating-modifier toxins. Pore-blocking toxins directly bind to the ion permeation pores of KV channels, thereby physically occluding them. In contrast, gating-modifier toxins bind to the voltage-sensor domains of KV channels, modulating their voltage-dependent conformational changes. These peptide toxins are useful molecular tools in revealing the structure-function relationship of KV channels and have potential for novel treatments for diseases related to KV channels. This review focuses on the inhibition mechanism of pore-blocking and gating-modifier toxins that target KV channels.

本文言語English
ホスト出版物のタイトルHandbook of Experimental Pharmacology
出版社Springer Science and Business Media Deutschland GmbH
ページ481-505
ページ数25
DOI
出版ステータスPublished - 2021

出版物シリーズ

名前Handbook of Experimental Pharmacology
267
ISSN(印刷版)0171-2004
ISSN(電子版)1865-0325

ASJC Scopus subject areas

  • 生化学
  • 薬理学、毒性学および薬学(全般)

フィンガープリント

「Peptide Toxins Targeting KV Channels」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル