Perceiving signals, building networks, reprogramming germ cell fate

Florencia Barrios, Naoko Irie, M. Azim Surani

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Germ cell development is a step-wise process that ensures the progression of the life cycle due to their unique ability to transmit their genome from one generation to the next. In the mouse, the precursors of germ cells, the Primordial Germ Cells (PGCs), arise at the onset of gastru-lation. Here we discuss how PGCs acquire their fate in the epiblast and outline their development until their arrival into the gonads. Male germ cell tumors (GCTs) have a similar gene expression pattern to that of fetal germ cells and to pluripotent cells, suggesting that GCT originate from an alteration of gonocyte normal development. We evaluate coincidences and differences in germ cell development in mouse and humans and on this basis, we speculate future research perspectives.

本文言語English
ページ(範囲)123-132
ページ数10
ジャーナルInternational Journal of Developmental Biology
57
2-4
DOI
出版ステータスPublished - 2013
外部発表はい

ASJC Scopus subject areas

  • 胎生学
  • 発生生物学

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