Perivascular nitric oxide gradients normalize tumor vasculature

Satoshi Kashiwagi, Kosuke Tsukada, Lei Xu, Junichi Miyazaki, Sergey V. Kozin, James A. Tyrrell, William C. Sessa, Leo E. Gerweck, Rakesh K. Jain, Dai Fukumura

研究成果: Article査読

117 被引用数 (Scopus)

抄録

Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.

本文言語English
ページ(範囲)255-257
ページ数3
ジャーナルNature medicine
14
3
DOI
出版ステータスPublished - 2008 3
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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