Personalization of repetitive transcranial magnetic stimulation for the treatment of major depressive disorder according to the existing psychiatric comorbidity

Po Han Chou, Yen Feng Lin, Ming Kuei Lu, Hsin An Chang, Che Sheng Chu, Wei Hung Chang, Taishiro Kishimoto, Alexander T. Sack, Kuan Pin Su

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.

本文言語English
ページ(範囲)190-205
ページ数16
ジャーナルClinical Psychopharmacology and Neuroscience
19
2
DOI
出版ステータスPublished - 2021 5

ASJC Scopus subject areas

  • 精神医学および精神衛生
  • 行動神経科学
  • 薬理学(医学)

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