Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy

Yutaka Kawakami, Boryana Popivanova, Sunthamala Nuchsupha, Taeko Hayakawa, Kenta Nakamura, Haruna Nagumo, Ikumi Katano, Tomonari Kinoshita, Kinya Tsubota, Hajime Kamijuku, Naoshi Kawamura, Junichiro Miyazaki, Ryosuke Satomi, Juri Sugiyama, Hiroshi Nishio, Shinobu Noji, Chie Kudo, Nobuo Tsukamoto, Toshiharu Sakurai, Tomonobu FujitaTomonori Yaguchi

研究成果: Chapter


Cancer immunotherapies utilizing tumor-specific T-cell responses, immune-checkpoint blockade, and T-cell-based adoptive cell therapy, have recently shown durable responses in advanced patients with various cancers. However, there are still cancer types and patients who do not respond to these immunotherapies. Pretreatment immune status varies in cancer patients, and it correlates with prognosis after various cancer therapies including immunotherapy. The differential T-cell response is defined by positive (e.g., number of immunogenic mutated peptides derived from mainly passenger DNA mutations in cancer cells, polymorphisms of immune-related genes of patients) and negative (e.g., oncogene activation including driver DNA mutations) immune pathways along with environmental factors (e.g., intestinal microbiota, diet, smoking, infection history). These factors could be biomarkers for selection of the patients who are likely to respond to immunotherapy and furthermore could be therapeutic targets to improve efficacy of immunotherapy possibly by combination immunotherapy with interventions on multiple key regulation points in the antitumor T-cell responses. Personalized combination immunotherapy based on the evaluation of T-cell immune status is a promising strategy for cancer treatment.

ホスト出版物のタイトルImmunotherapy of Cancer
ホスト出版物のサブタイトルAn Innovative Treatment Comes of Age
出版社Springer Japan
出版ステータスPublished - 2016 2月 22

ASJC Scopus subject areas

  • 医学(全般)


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