Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.
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