Peyer's patch organogenesis as a programmed inflammation: A hypothetical model

Shin Ichi Nishikawa, Satomi Nishikawa, Kenya Honda, Hiroyuki Hashi, Hisahiro Yoshida

研究成果: Short survey査読

26 被引用数 (Scopus)

抄録

Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.

本文言語English
ページ(範囲)213-220
ページ数8
ジャーナルCytokine and Growth Factor Reviews
9
3-4
DOI
出版ステータスPublished - 1998 12 1
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 免疫アレルギー学
  • 免疫学
  • 生化学、遺伝学、分子生物学(全般)

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