Pharmacokinetic properties of hemoglobin vesicles as a substitute for red blood cells

Kazuaki Taguchi, Toru Maruyama, Masaki Otagiri

研究成果: Review article査読

16 被引用数 (Scopus)

抄録

The development of artificial oxygen carriers has attracted considerable recent interest because of the increasing cost of collecting and processing blood, public concerns about the safety of blood products, complications from blood transfusions, military requirements for increased volumes of blood during military conflicts, and a decrease in the number of new donors. To overcome these problems, perfluorocarbon-based oxygen carriers as well as acellular-and cellular-type, hemoglobin-based oxygen carriers have been developed for use as artificial oxygen carriers. Despite their extensive evaluation, including formulation and pharmacology, they have not been extensively used in clinical settings. One of the reasons for this is that their pharmacokinetics have not been well characterized. Artificial oxygen carriers require not only an acceptable level of physicochemical activity, but also clinical efficacy, as reflected by their retention in the circulation, and the absence of measurable accumulation in the body, if unexpected adverse effects are to be avoided. In this review, the pharmacokinetic properties of artificial oxygen carriers are discussed, with a focus on recent developments of our research related to the pharmacokinetic properties a cellular type of hemoglobin-based oxygen carrier.

本文言語English
ページ(範囲)362-373
ページ数12
ジャーナルDrug Metabolism Reviews
43
3
DOI
出版ステータスPublished - 2011 8月 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学、毒性学および薬学(全般)
  • 薬理学(医学)

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