Pharmacokinetically modified human serum albumin based therapeutic design and development

Kazuaki Taguchi, Victor Tuan Giam Chuang, Keishi Yamasaki, Masaki Otagiri

研究成果: Chapter

抄録

Human serum albumin (HSA) is synthesized predominantly in the liver, and has an extraordinarily long circulatory half-life (~19 days). Since HSA is responsible for 80% of the colloidal osmotic pressure of plasma, the patients with hypoalbuminemia are typically given a plasma expander to increase the plasma volume. Clinically, using HSA as an extender is preferable to other options, such as dextran, hydroxylethyl starch, due to its long retention in plasma. However, the circulatory half-life of HSA is significantly- impacted by structural changes of HSA and pathological conditions. Recent scientific advances have revealed new information regarding the factors that influence the pharmacokinetic properties of HSA. In this chapter, we provide an overview of the impact of HSA structure and biotransformation upon the pharmacokinetic properties of HSA, and discuss new possibilities for the therapeutic potential of HSA based on its pharmacokinetic properties.

本文言語English
ホスト出版物のタイトルHuman Serum Albumin (HSA)
ホスト出版物のサブタイトルFunctional Structure, Synthesis and Therapeutic Uses
出版社Nova Science Publishers, Inc.
ページ69-89
ページ数21
ISBN(電子版)9781634830157
ISBN(印刷版)9781634829632
出版ステータスPublished - 2015 7 1
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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