Pharmacological therapies for ARDS

Hiroaki Izumida, Seitaro Fujishima

研究成果: Review article査読

抄録

Acute respiratory distress syndrome (ARDS) is a non-cardiogenic pulmonary edema resulting from increased capillary permeability. Numerous pharmacologic therapies have been studied for prevention and treatment of ARDS. Although several pharmacological therapies could improve patient's respiratory function, there have been no controlled studies which clearly demonstrated the clinical benefit for ARDS-related mortality. The role of corticosteroids in ARDS remains controversial. Available evidence is against early administration of high-dose corticosteroids (methylprednisolon 120 mg·kg-1·day -1). In contrast, low-dose corticosteroid therapy (methylprednisolon 0.5-2.5 mg·kg-1·day-1)remains controversial. With regard to sivelestat sodium, a specific inhibitor of neutrophil elastase, although the effectiveness in decreasing mortality was not clarified, increases in lung oxygenation and ventilator-free days have consistently been revealed. Other probable pharmacologic therapies for ARDS include continuous infusion of cisatracurium. In conclusion, there are not established drugs for ARDS, and further studies are necessary to reveal the clinical effectiveness of the above mentioned and novel pharmacologic therapies.

本文言語English
ページ(範囲)541-546
ページ数6
ジャーナルJapanese Journal of Anesthesiology
62
5
出版ステータスPublished - 2013 5 1

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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