Phase I study of FK 435

O. Abe, K. Enomoto, K. Fujiwara, M. Izuo, Y. Iino, T. Tominaga, K. Hayashi, O. Takatani, N. Kugai, M. Yoshida

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We performed phase I study of FK 435, a new antiestrogen, in 30 patients with advanced breast cancer. Slight to moderate adverse reactions were noted as follows. Single-dose study: anorexia, nausea, lassitude in one patient (80 mg), decreased serum calcium in one (160 mg), redness, tenderness in one, facial flushing, hot flushes, headache in one (320 mg). Repeated-dose study: anorexia, nausea in one patient (40 mg/day), anorexia, diarrhea, increased FSH in one, increased PRL in one (80 mg/day). FK 435 was well tolerated. Tmax was 3-5 hours, T1/2 about 25 hours. Most of FK 435 was excreted into urine as glucuronide.

本文言語English
ページ(範囲)903-913
ページ数11
ジャーナルGan no rinsho. Japan journal of cancer clinics
36
8
出版ステータスPublished - 1990 7月 1

ASJC Scopus subject areas

  • 医学(全般)

フィンガープリント

「Phase I study of FK 435」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル