Phase i study of s-1 plus fractional cisplatin as adjuvant chemotherapy for advanced gastric cancer in an outpatient setting (KOGC-03)

Tsunehiro Takahashi, Yoshirou Saikawa, Kazumasa Fukuda, Rieko Nakamura, Norihito Wada, Hirofumi Kawakubo, Hiroya Takeuchi, Hiromasa Takaishi, Yuko Kitagawa

研究成果: Article査読

抄録

Aim: The aim of this phase I study was to adjust the dose of cisplatin as adjuvant combination chemotherapy with S-1 in an outpatient setting for gastric cancer.

Patients and Methods: The first course was initiated with S-1 monotherapy on days 1-28. From the second to the sixth course, S-1 was administered on days 1-28 and cisplatin was added on days 1, 15, and 29. The dose level of cisplatin was escalated as follows: 20 mg/m2 (level 1); 25 mg/m2 (level 2); 30 mg/m2 (level 3). Dose-limiting toxicity was a delay factor of the start of the next course due to incomplete recovery.

Results: The maximum tolerated and recommended doses were confirmed as level 3 and level 2, respectively.

Conclusion: Although further clinical trials are recommended to evaluate efficacy, this combination of S-1 plus cisplatin regimen is expected to become a standard adjuvant treatment for gastric cancer in the outpatient setting.

本文言語English
ページ(範囲)467-472
ページ数6
ジャーナルAnticancer research
35
1
出版ステータスPublished - 2015 1 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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