Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line

Seiji Miyake, Saori Kobayashi, Kazuo Tsubota, Yoko Ozawa

研究成果: Article査読

18 被引用数 (Scopus)

抄録

The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina.

本文言語English
ページ(範囲)535-540
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
446
2
DOI
出版ステータスPublished - 2014 4 4

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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