TY - GEN
T1 - Phase-separated core-shell hydrogel microbeads from homogeneous mixed polymer solution by simultaneous gelation
AU - Kurashina, Yuta
AU - Tsuchiya, Mio
AU - Kasahara, Keitaro
AU - Onoe, Hiroaki
N1 - Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - We propose a generation method of the hydrogel microbeads with the core-shell structure based on phase separation of homogeneous polymer solution mixed with sodium alginate and N-isopropylacrylamide (NIPAM). Without using oil phase and tubing/pumping apparatus, centrifugally generated microdroplets of photocrosslinkable monomer solution can be polymerized by UV irradiation with the assistant of ionic gelation of alginate hydrogel. By using the centrifugal microfluidic device with UV LEDs, the homogeneous mixed polymer solution was successfully turned into hydrogel microbeads with the phase-separated core-shell structure with simultaneous photo-polymerization and ionic crosslink. We envision that our proposed core-shell hydrogel microbeads would be useful tools for functional drug delivery systems and health monitoring biochemical sensors for in vivo applications.
AB - We propose a generation method of the hydrogel microbeads with the core-shell structure based on phase separation of homogeneous polymer solution mixed with sodium alginate and N-isopropylacrylamide (NIPAM). Without using oil phase and tubing/pumping apparatus, centrifugally generated microdroplets of photocrosslinkable monomer solution can be polymerized by UV irradiation with the assistant of ionic gelation of alginate hydrogel. By using the centrifugal microfluidic device with UV LEDs, the homogeneous mixed polymer solution was successfully turned into hydrogel microbeads with the phase-separated core-shell structure with simultaneous photo-polymerization and ionic crosslink. We envision that our proposed core-shell hydrogel microbeads would be useful tools for functional drug delivery systems and health monitoring biochemical sensors for in vivo applications.
KW - Centrifugal microfluidics
KW - Core-shell structure
KW - Microparticles
KW - N-isopropylacrylamide
KW - Phase separation
KW - Photo polymerization
UR - http://www.scopus.com/inward/record.url?scp=85083168762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083168762&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85083168762
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 910
EP - 911
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -