Phenylethanoid glycosides targeting mammalian DNA polymerases

Akira Iida, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshiyuki Mizushina, Horomi Yoshida, Kanat Sarsenbaev

研究成果: Article

3 引用 (Scopus)

抜粋

In our continuing search to discover bioactive compounds from medicinal plants, a methanolic extract of Verbascum songaricum collected in Kazakhstan was investigated. Activity-guided fractionation of the extract prepared from the plant, using a sensitive assay to monitor DNA polymerase reactions, resulted in the isolation of two known phenylethanoid glycosides, poliumoside (1) and verbascoside (2). Glycoside 1 was shown to inhibit mammalian DNA polymerases α, β, δ and ε with IC50 values of 42, 23, 35 and 9 [μM, respectively, while those of glycoside 2 were all more than 100 [μM.

元の言語English
ページ(範囲)146-149
ページ数4
ジャーナルNatural Medicines
57
発行部数4
出版物ステータスPublished - 2003 8 1
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • Molecular Medicine

これを引用

Iida, A., Kiuchi, F., Ito, M., Honda, G., Mizushina, Y., Yoshida, H., & Sarsenbaev, K. (2003). Phenylethanoid glycosides targeting mammalian DNA polymerases. Natural Medicines, 57(4), 146-149.