Phenylethanoid glycosides targeting mammalian DNA polymerases

Akira Iida, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshiyuki Mizushina, Horomi Yoshida, Kanat Sarsenbaev

研究成果: Article

3 引用 (Scopus)

抄録

In our continuing search to discover bioactive compounds from medicinal plants, a methanolic extract of Verbascum songaricum collected in Kazakhstan was investigated. Activity-guided fractionation of the extract prepared from the plant, using a sensitive assay to monitor DNA polymerase reactions, resulted in the isolation of two known phenylethanoid glycosides, poliumoside (1) and verbascoside (2). Glycoside 1 was shown to inhibit mammalian DNA polymerases α, β, δ and ε with IC50 values of 42, 23, 35 and 9 [μM, respectively, while those of glycoside 2 were all more than 100 [μM.

元の言語English
ページ(範囲)146-149
ページ数4
ジャーナルNatural Medicines
57
発行部数4
出版物ステータスPublished - 2003 8
外部発表Yes

Fingerprint

DNA-Directed DNA Polymerase
Glycosides
Verbascum
Kazakhstan
Plant Extracts
Medicinal Plants
Fractionation
Inhibitory Concentration 50
Assays

ASJC Scopus subject areas

  • Molecular Medicine

これを引用

Iida, A., Kiuchi, F., Ito, M., Honda, G., Mizushina, Y., Yoshida, H., & Sarsenbaev, K. (2003). Phenylethanoid glycosides targeting mammalian DNA polymerases. Natural Medicines, 57(4), 146-149.

Phenylethanoid glycosides targeting mammalian DNA polymerases. / Iida, Akira; Kiuchi, Fumiyuki; Ito, Michiho; Honda, Gisho; Mizushina, Yoshiyuki; Yoshida, Horomi; Sarsenbaev, Kanat.

:: Natural Medicines, 巻 57, 番号 4, 08.2003, p. 146-149.

研究成果: Article

Iida, A, Kiuchi, F, Ito, M, Honda, G, Mizushina, Y, Yoshida, H & Sarsenbaev, K 2003, 'Phenylethanoid glycosides targeting mammalian DNA polymerases', Natural Medicines, 巻. 57, 番号 4, pp. 146-149.
Iida A, Kiuchi F, Ito M, Honda G, Mizushina Y, Yoshida H その他. Phenylethanoid glycosides targeting mammalian DNA polymerases. Natural Medicines. 2003 8;57(4):146-149.
Iida, Akira ; Kiuchi, Fumiyuki ; Ito, Michiho ; Honda, Gisho ; Mizushina, Yoshiyuki ; Yoshida, Horomi ; Sarsenbaev, Kanat. / Phenylethanoid glycosides targeting mammalian DNA polymerases. :: Natural Medicines. 2003 ; 巻 57, 番号 4. pp. 146-149.
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AU - Yoshida, Horomi

AU - Sarsenbaev, Kanat

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