In our continuing search to discover bioactive compounds from medicinal plants, a methanolic extract of Verbascum songaricum collected in Kazakhstan was investigated. Activity-guided fractionation of the extract prepared from the plant, using a sensitive assay to monitor DNA polymerase reactions, resulted in the isolation of two known phenylethanoid glycosides, poliumoside (1) and verbascoside (2). Glycoside 1 was shown to inhibit mammalian DNA polymerases α, β, δ and ε with IC50 values of 42, 23, 35 and 9 [μM, respectively, while those of glycoside 2 were all more than 100 [μM.
|出版物ステータス||Published - 2003 8 1|
ASJC Scopus subject areas
- Molecular Medicine