Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

Tsuyoshi Osawa, Teppei Shimamura, Kyoko Saito, Yoko Hasegawa, Naoko Ishii, Miyuki Nishida, Ritsuko Ando, Ayano Kondo, Muyassar Anwar, Rika Tsuchida, Shinjiro Hino, Akihisa Sakamoto, Kaori Igarashi, Kaori Saitoh, Keiko Kato, Keiko Endo, Shotaro Yamano, Yasuharu Kanki, Yoshihiro Matsumura, Takashi MinamiToshiya Tanaka, Motonobu Anai, Youichiro Wada, Hideki Wanibuchi, Mitsuhiro Hayashi, Akinobu Hamada, Masayuki Yoshida, Shinichi Yachida, Mitsuyoshi Nakao, Juro Sakai, Hiroyuki Aburatani, Masabumi Shibuya, Kentaro Hanada, Satoru Miyano, Tomoyoshi Soga, Tatsuhiko Kodama

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Osawa et al. find that accumulation of phosphoethanolamine (PEtn) protects cancer cells under glutamine starvation through the downregulation of PCYT2. Glutamine regulates PE biosynthesis through PCYT2, resulting in pro-tumorigenic metabolite PEtn accumulation. PEtn stimulates the tolerance of cancer cells to starvation, and lowered PCYT2 expression correlates with decreased survival in patients.

本文言語English
ページ(範囲)89-103.e7
ジャーナルCell Reports
29
1
DOI
出版ステータスPublished - 2019 10 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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