Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics

Naoki Kanoh, Kaori Honda, Sim Simizu, Makoto Muroi, Hiroyuki Osada

研究成果: Article査読

87 被引用数 (Scopus)

抄録

(Figure Presented) A photoaffinity reaction has been used to photo-cross-link small molecules on agarose beads to identify and purify the binding proteins (see picture; PMF: peptide mass fingerprinting). This technology is considered potentially useful for the confirmation of specificity between a small molecule and a protein of interest in the field of reverse chemical genetics.

本文言語English
ページ(範囲)3559-3562
ページ数4
ジャーナルAngewandte Chemie - International Edition
44
23
DOI
出版ステータスPublished - 2005 6 6
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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